Tracking crystallophore nucleating properties: setting-up a database for statistical analysis [article]

Eric Girard, Tao Jiang, Amandine Roux, Sylvain Engilberge, Zaynab Alsalman, Sebastiano Di Pietro, Bruno Fanzetti, Francois Riobe, Olivier Maury
2020 biorxiv/medrxiv   pre-print
In this article, the principle of a database aimed at facilitating the understanding of the unique protein nucleating properties of the Crystallophore is presented. A first analysis allows us to compare the efficiency of Tb-Xo4 with the new Lu-Xo4 variant, featuring improved phasing properties. Then, the concept of subset-of-interest is introduced to reveal potential antagonistic/synergistic effects between Tb-Xo4 and physico-chemical parameters of the crystallisation kits such as pH. The
more » ... ch as pH. The overall approach may be of interest for any studies working on solutions dedicated to improve the nucleating step in protein crystallization.
doi:10.1101/2020.04.23.057596 fatcat:3fp5d6kvmradrl6afldj2hzr6u