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The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure
The Journal of General Physiology
Human ether-à-go-go–related gene (hERG, KCNH2) voltage-activated potassium channels are critical for cardiac excitability. hERG channels have characteristic slow closing (deactivation), which is auto-regulated by a direct interaction between the N-terminal Per-Arnt-Sim (PAS) domain and the C-terminal cyclic nucleotide binding homology domain (CNBHD). hERG channels are not activated by the binding of extrinsic cyclic nucleotide ligands, but rather bind an "intrinsic ligand" that is composed ofdoi:10.1085/jgp.201812129 pmid:30425124 fatcat:vmvv57cfnbf6hp3fazscw2pr4m