The in vivo localization of a polyclonal antibody (GP68 PoAb) against a glycoprotein, which was found in developing mouse brain, was studied in murine tumor model. The biodistribution of 125I-GP68 PoAb 3 days postinjection into the mice bearing eight different kinds of solid tumor represented a high uptake ratio by metastatic lung cancer, mammary tumor such as MMT 060562 and adenocarcinoma 755, and melanoma B-16. In immunoscintigraphic studies, adenocarcinoma 755 and metastatic lung cancer were

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... successfully visualized with 131I-GP68 PoAb at 3 days postinjection . The strongly positive images of these tumors with 131I-GP68 PoAb were accorded well with the data on tissue distribution of this antibody . These results suggest that GP 68 PoAb may be applicable to the detection of the mammary and/or metastatic lung cancer.