Usage of recombinant human erythropoietin in surgical operations in the animal model

Fumimaro Takaku, Hirofumi Arai, Mayumi Kawagishi, Yoshiko Yoshihara, Masaru Kusaka
1988 Journal of the Japan Society of Blood Transfusion  
To study a possibility of using recombinant human erythropoietin (r-HuEPO) for the prevention and treatment of anemia associated with surgical operations, rats were phlebotomized and effects of administration of r-HuEPO on subsequent anemia were observed. Injection of r-hEPO prior or subsequent to blood-letting amounting 1% of body weight prevented or accelerated the recovery from anemia. Blood-letting amounting 2% of body weight induced a severe anemia in control rats. Prior injection of large
more » ... amounts of r-HuEPO (1600 U/kg) lessened significantly the degree of anemia. It is suggested that the r-HuEPO can be very useful for the prevention of anemia associated with surgical operations. It also can be used to accelerate the recovery from anemia. Prior injection of r-HuEPO can also be very useful for autologous blood transfusion in surgical operations.
doi:10.3925/jjtc1958.34.11 fatcat:dzpkvg5bjnct5a7m6kmpwkoede