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Factors Impacting Variability of the Urinary Normeperidine-to-Meperidine Metabolic Ratio in Patients with Chronic Pain
Journal of Analytical Toxicology
Meperidine (Demerol w ) is a mu-and kappa-opiate receptor agonist used for moderate to severe pain. Overdose can result in respiratory depression, hypotension and coma, while accumulation of its toxic metabolite, normeperidine, can cause delirium and seizures. Little data exist examining the inter-and intrasubject variability of the normeperidine-to-meperidine metabolic ratio (MR) in urine. This retrospective data analysis examined meperidine and normeperidine urine concentrations collecteddoi:10.1093/jat/bkt087 pmid:24133175 fatcat:oehpq6zstnd4fmbb7ejpalnboq