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The Physics of Entropic Pulling: A Novel Model for the Hsp70 Motor Mechanism
2019
International Journal of Molecular Sciences
Hsp70s use ATP to generate forces that disassemble protein complexes and aggregates, and that translocate proteins into organelles. Entropic pulling has been proposed as a novel mechanism, distinct from the more familiar power-stroke and Brownian ratchet models, for how Hsp70s generate these forces. Experimental evidence supports entropic pulling, but this model may not be well understood among scientists studying these systems. In this review we address persistent misconceptions regarding the
doi:10.3390/ijms20092334
fatcat:vt7lsywa6vfetcj7p5npwapoie