A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation
Poly-adenosine diphosphate (ADP)-ribosylation of nuclear proteins has been demonstrated previously to be activated in vivo by the presence of DNA single-strand breaks and has thus been implicated to play an important role in altering chromatin structure during cellular recovery from DNA damage. Based upon these considerations, a novel immunofractionation method, using antipoly(ADP-ribose) coupled to Sepharose, has been used to enrich for those limited domains of chromatin undergoingpmid:3917373 fatcat:4mooop5eerhofnylqb6djx2z3q