A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2011; you can also visit the original URL.
The file type is application/pdf
.
The Evolution of Transcriptional Regulation in Eukaryotes
2003
Molecular biology and evolution
Gene expression is central to the genotype-phenotype relationship in all organisms, and it is an important component of the genetic basis for evolutionary change in diverse aspects of phenotype. However, the evolution of transcriptional regulation remains understudied and poorly understood. Here we review the evolutionary dynamics of promoter, or cisregulatory, sequences and the evolutionary mechanisms that shape them. Existing evidence indicates that populations harbor extensive genetic
doi:10.1093/molbev/msg140
pmid:12777501
fatcat:zxbivtxbczbhhft5t3iyspf3mm