摘要 目的:研究老年性黄斑变性(AMD) 等级、血清抗氧化维生 素水平(维生素 A、C 和 E) 和吸烟的关系。 方法:对 84 例患者行黄斑彩色眼底成像,根据 AMD 损伤 率和损伤程度将其分为五组(等级 I ~ V) 。 应用高效液相 色谱法(HPLC) 测量血清抗氧化维生素水平。 根据吸烟状 况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每 年的吸烟总量。 结果:对照组中,维生素 A、E、C 水平分别为 0. 874依0. 326mg / L, 10. 739依4. 874mg / L 和 1. 737 依0. 447mg / L,AMD 组中分别 为 0. 880 依 0. 305mg / L, 9. 487 依 6. 060mg / L 和 1. 870 依 2郾 191mg / L,无显著差异(P >0. 05) 。 AMD 不同等级分组 间维生素 A(P = 0. 881) 和 E(P = 0. 293) 水平差异无统计 学意义,维生素 C 水平(P = 0. 044) 随 AMD 程度的加深而 增加。 根据吸烟状况,AMD 组与对照组之间无显著差异。

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... 量,两组之间有显著差异(P = 0. 02) 。 AMD 越严重,年吸烟总量越高(P = 0. 007) 。 Abstract 誗 AIM: To evaluate associations between the grades of age related macular degeneration (AMD) and serum levels of antioxidant vitamins (vitamin A, C and E) and smoking. 誗METHODS: Fifty-three AMD patients and 31 individuals having ages matching with the patient group were enrolled the study. Colored fundus photographs of the macula were used to place participants (n = 84) into one of the five groups (Grade I-V) based on the frequency and severity of the lesions associated with AMD. Serum antioxidant vitamin levels were measured using High Performance Liquid Chromatography (HPLC). Smoking status was classified as non-smoker, ex-smoker and current smoker. Total number of packs smoked per year, was defined. 誗RESULTS: The distribution of vitamin A, E, and C levels were 0. 874 依 0. 326mg / L, 10. 739 依 4. 874mg / L, 1. 737 依 0郾 447mg / L in control group and 0. 880依0. 305mg / L, 9. 487依 6. 060mg / L, 1. 870 依 2. 191mg / L in AMD group, respectively. The difference between AMD and control group was not statistically significant for vitamin A, E and C levels (P > 0郾 05). There were no significant differences between subgroups of AMD for vitamin A (P = 0. 881) and vitamin E (P = 0. 293) but there was a contradicting rise of vitamin C levels (P = 0. 044) with increasing levels of the disease. There were no significant differences between AMD and control group regarding smoking status, but there was a significant difference for total number of packs smoked per year (P = 0. 02). An increase of number of total packs smoked per year was determined along with the rising grade of AMD (P = 0. 007). 誗CONCLUSION: We found no relation between AMD and serum levels of vitamin A and E but vitamin C levels was increase with AMD grades unexpectedly. We found dose-response relationship between smoking and AMD.