Original Article Correlation between AEG-1 gene polymorphisms and osteosarcoma susceptibility

Wenlong Zhang, Na Ge, Lele Dong, Jianqiang Lian, Jinlei Sun, Yanping Zheng
2017 Int J Clin Exp Pathol   unpublished
Aim: The objective of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of the astrocyte elevated gene-1 (AEG-1) gene (rs16896059 and rs1311) and osteosarcoma (OS) susceptibility in Chinese Han population. Methods: The case and control groups were evaluated by Hardy-Weinberg equilibrium (HWE). Genotype and allele frequencies of the two polymorphisms were obtained by direct calculation. Differences of the genotyes and alleles of these polymorphisms were
more » ... lymorphisms were assessed by Chi-square test. Relative risk of OS was represented by odds ratios (ORs) with 95% confidence intervals (CIs). Results: Frequencies of AA genotype and A allele of rs16896059 SNP between OS patients and healthy individuals were significantly different (P<0.05). AA genotype and A allele may be protective against OS onset respectively (OR=0.258, 95% CI=0.068-0.986; OR=0.628, 95% CI=0.401-0.985). However, there was no significant differences of the genotype and allele distributions of AEG-1 gene rs1311 polymorphism between case and control groups (P>0.05). Conclusion: AEG-1 gene rs16896059 polymorphism act as a protect factor for the occurrence of OS. But rs1311 had no significant association with the OS risk.