Original Article Correlation between AEG-1 gene polymorphisms and osteosarcoma susceptibility
Int J Clin Exp Pathol
Aim: The objective of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of the astrocyte elevated gene-1 (AEG-1) gene (rs16896059 and rs1311) and osteosarcoma (OS) susceptibility in Chinese Han population. Methods: The case and control groups were evaluated by Hardy-Weinberg equilibrium (HWE). Genotype and allele frequencies of the two polymorphisms were obtained by direct calculation. Differences of the genotyes and alleles of these polymorphisms were
... lymorphisms were assessed by Chi-square test. Relative risk of OS was represented by odds ratios (ORs) with 95% confidence intervals (CIs). Results: Frequencies of AA genotype and A allele of rs16896059 SNP between OS patients and healthy individuals were significantly different (P<0.05). AA genotype and A allele may be protective against OS onset respectively (OR=0.258, 95% CI=0.068-0.986; OR=0.628, 95% CI=0.401-0.985). However, there was no significant differences of the genotype and allele distributions of AEG-1 gene rs1311 polymorphism between case and control groups (P>0.05). Conclusion: AEG-1 gene rs16896059 polymorphism act as a protect factor for the occurrence of OS. But rs1311 had no significant association with the OS risk.