Acute lymphoblastic leukemia in childhood. A 10-year experience with the DFCI 81-01 protocol
Leucemia linfoblástica aguda na criança. Experiência de dez anos com o protocolo DFCI 81-01

A F de Lacerda, M Chagas, A Neto, E Vieira, M J Ribeiro, F Pereira, A Ambrósio, M Sousinha
Acta Médica Portuguesa  
Acute lymphoblastic leukemia is the most frequently encountered pediatric cancer. Approximately 70% of cases can be cured of the disease. In this article, we describe the experience of our Center in the last ten years with a treatment protocol adapted from protocol DFCI 81-01 (from the Dana Farber Cancer Institute, Boston). We conclude that it is easily accomplished, well tolerated and that it allowed us to significantly improve the outcome of our patients (80% 5 year-survival). Nevertheless,
more » ... are currently in the process of changing to a new protocol--one that will hopefully achieve a comparable cure rate with less long-term toxicity.
pmid:10707467 fatcat:r7kx4u2luba3ribr4ee3uuu2ye