Study of Sedation, Pre-anesthetic and Anti-anxiety Effects of Salix Aegyptiaca Herbal Extract in Comparison with Diazepam in Rats

Ali Razaei Ali Razaei
2013 IOSR Journal of Pharmacy and Biological Sciences  
salix herb to mediate the effect of sedation, anti-spasmodic and analgesic in Europe traditional medicine and most countries have had a special status and also in Iran since ancient is used as herbal extract, as well as salix extract has many therapeutic properties. Because this plant hasmany alkaloids, phenols andflavonoidsare constantly used for reducing the nerve pressure, treatment of chronic insomnia, depression, create a calming effect and appealed to the restoration of skin.With noticeof
more » ... skin.With noticeof synthetic drugsside effects and economic issues we sensed to need that to compare of anti-anxiety and pre anesthetic effects of the extracts of this plant with the synthetic drugs. Methods: In different groups of Wistar male rats, the extract ofSalix Aegyptiacawith doses of 100 mg/kg, 200 mg/kg and 400 mg/kg and diazepam with 1.2 mg/kgwere injected andDimethyl sulfoxide with the same volume 30 minutes prior to the assessment of the effects of sedation and anesthesia (sleeping period induced with ketamine) with the dose of 40 mg/kg was injected and for evaluating of the anti-anxiety effects "Elevated plus maze"was used. Results: The achieved results represent a significant increase for sleeping that induced by ketamine, as well as a significant increase in the time expired in the open arms in the treated group with 200 mg/kg of extract.Conclusion: The results showed that the salixextract with a dose of 200 mg/kg has the effects of pre-anesthesia, and anti-anxiety.
doi:10.9790/3008-0621720 fatcat:arlzvf4m2bfdnapm55lyoccfzy