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1,25-Dihydroxyvitamin D3Induces Phospholipase D-1 Expression in Primary Mouse Epidermal Keratinocytes
Journal of Biological Chemistry
The hormone 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) elicits the programmed pattern of differentiation in epidermal keratinocytes. Based on data indicating a potential role of phospholipase D (PLD) in mediating keratinocyte differentiation, we investigated the effect of 1,25(OH) 2 D 3 on PLD expression. A 24-h exposure to 1,25(OH) 2 D 3 stimulated PLD-1, but not PLD-2, mRNA expression. This 1,25(OH) 2 D 3 -enhanced expression was accompanied by increased total PLD and PLD-1 activity. Timedoi:10.1074/jbc.274.8.4663 pmid:9988703 fatcat:i3ldok6livacnfj2tzbjm3niuy