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Hormesis and Exercise: How the Cell Copes with Oxidative Stress
2008
American Journal of Pharmacology and Toxicology
Contraction-induced production of reactive oxygen and nitrogen species has been shown to cause oxidative stress to skeletal muscle, heart and other organs. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise to restore intracellular prooxidantantioxidant homeostasis. Thus, both young and old animals and humans involved in regular exercise have shown reduced oxidative damage during acute physical exertion at accustomed or excessive intensity, or
doi:10.3844/ajptsp.2008.44.58
fatcat:f5xt6cmbobgkxg2f3qe4usm7xy