SERPINB9 expression associates with survival in triple negative breast cancer [post]

Shahan Mamoor
2021 unpublished
We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival following treatment: dead or alive. We observed significant transcriptome-wide differential expression of serpin peptidase inhibitor, clade B (ovalbumin), member 9, encoded by SERPINB9 when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, SERPINB9 expression was correlated
more » ... with recurrence-free survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. SERPINB9 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
doi:10.31219/ fatcat:s6i3klh57zaz3ivnawtxuku5uq