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Polyphenols and Alzheimer's Disease: Tau/polyphenol interactions investigated by NMR and molecular modelling
Nutrition and Aging
Tau that belongs to the family of microtubule-associated proteins is the major constituent of intraneuronal fibrillar lesions described in Alzheimer's Disease (AD). Its sequence homology with salivary proline-rich proteins (sPRP), known to fix tannins, combined with some epidemiological evidences that a moderate consumption of polyphenols presents benefits in AD, suggests that tannins can bind Tau protein and, perhaps, could inhibit or modulate the cascade of events leading to AD symptoms. Todoi:10.3233/nua-130015 fatcat:y4kyj6oambdbpnp25jbk4fl7ou