SIMPLE VALIDATION OF AZELNIDIPINE BY RP-HPLC METHOD

Selvadurai Muralidharan, Subramaniya Parasuraman, Vijayan Venugopal
2015 Rapports De Pharmacie   unpublished
A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the estimation of Azelnidipine from pharmaceutical Tablet dosage form. The method was carried out on a C 18 (250 mm x 4.6 mm i.d., 5 µ) column with a mobile phase consisting of acetonitrile: 0.5% triethyl amine (adjusted to pH 3.5 using orthophosphoric acid) (70:30 v/v) at a flow rate of 1.0 ml/min. Detection was carried out at 254 nm. The retention time of
more » ... ion time of Azelnidipine was 4.9 min. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the routine analysis.
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