Clinicopathological Diversity of Pancytopenia: A Series of 400 Cases

Sridevi Hanaganahalli Basavaiah, Sharada Rai, Pooja Kundapur Suresh, Somesh Meludurgamata Shivaprasad, Binit Khandelia
2018 Journal of Clinical and Diagnostic Research  
Pancytopenia is a diagnostically challenging entity encountered commonly in routine clinical practice. It is not a disease entity by itself but an expression of an underlying disorder that can either be a haematopoietic or a non haematopoietic condition. It is characterised by the reduction of Red Blood Cells (RBCs), White Blood Cells (WBCs) and platelets below the normal reference range [1]. Initially, most of the clinical manifestations can be attributed to anaemia and thrombocytopenia,
more » ... r, leukopenia is encountered late in the disease [2] . The underlying mechanisms maybe secondary to decreased marrow production, marrow infiltration, bone marrow suppression, ineffective haematopoiesis or increased peripheral destruction [2, 3] . There are many studies in the literature stating the various causes of pancytopenia [1] [2] [3] . This study aimed to evaluating the clinicopathological profile of pancytopenia. The study also aimed to know whether there is a need for a bone marrow examination in every case of pancytopenia and also the importance of ancillary tests to identify the cause. To the best of our knowledge, this is the largest study from the Indian subcontinent. StAtIStICAL AnALySIS Data was analysed using SPSS 22.0 version software and the test of significance was performed by chi-square test. A p-value <0.05 was considered of statistical significant. RESuLtS A total of 400 patients with pancytopenia were included in the study, and bone marrow aspiration was performed in 200 cases, out of which biopsy correlation was available in 77 cases. The age ranged from two days to 90 years (mean±SD age: 34±19.6 years). The
doi:10.7860/jcdr/2018/32116.11227 fatcat:5r2fghxwbjevdia3ktpgkk7mcq