Antiplasmodial, acetylcholinesterase and alpha-glucosidase inhibitory and cytotoxicity properties of Buddleja saligna

Jude C. Chukwujekwu, Stephen O. Amoo, Carmen A. de Kock, Peter J. Smith, Johannes Van Staden
2014 South African Journal of Botany  
The crude ethanolic extract, hexane, dichloromethane, ethyl acetate and aqueous fractions of Buddleja saligna leaves were investigated for antiplasmodial, alpha-glucosidase and acetylcholinesterase inhibitory and cytotoxicity properties. Although the crude extract displayed some level of activity, the hexane fraction demonstrated the best antiplasmodial (IC 50 = 8.5 μg/ml), alpha-glucosidase inhibitory (IC 50 = 260 μg/ml) and anticholinesterase (IC 50 = 124.8 μg/ml) activities. The safety index
more » ... s. The safety index values of the hexane fraction [antiplasmodial (0.2), alphaglucosidase inhibition (0.007) and anticholinesterase (0.01)] revealed that the fraction is cytotoxic. These findings highlight the importance of reporting the SI values of biologically active samples together with their biological activities. It remains to be determined whether the toxicity observed is caused by the compounds responsible for the biological activities investigated or not.
doi:10.1016/j.sajb.2014.05.003 fatcat:jg67ineq6reajmvlf4ywvltayy