Stabilization or regression of atherosclerosis by lifestyle modification using motivational interviewing and carotid ultrasound

J.R.M. Blekemolen, J.D. Barth, M.M.B. Zonjee
2011 Artery Research  
p< 0.05), augmentation index (AIx, 22.0AE7.0 vs 13.1AE5.2%, p<0.01) and pressure-dependent elastic modulus. After barnidipine, in hypertensive patients, office BP fell from 159AE14/95AE11 to 138AE16/81AE9 mmHg (p<0.001), due to a significant reduction in forward and backward pressures, and AIx decreased to 17.0AE8.0% (p<0.01), without changes in arterial stiffness indices. A significant direct relationship between AIx and pulse pressure observed in hypertensive patients at baseline disappeared
more » ... seline disappeared after therapy (rZ0.45 before and 0.25 after therapy). Conclusions. These data suggest that a reduced wave reflection during therapy with the calcium antagonist barnidipine is depending on its effects on muscular artery tone rather than on large artery stiffness.
doi:10.1016/j.artres.2011.10.144 fatcat:ffibzf56bjcdlg5taokx5u7nnu