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Post-transcriptional Regulation of the Yeast High Affinity Iron Transport System
2005
Journal of Biological Chemistry
Saccharomyces cerevisiae transcriptionally regulates the expression of the plasma membrane high affinity iron transport system in response to iron need. This transport system is comprised of the products of the FET3 and FTR1 genes. We show that Fet3p and Ftr1p are post-translationally regulated by iron. Incubation of cells in high iron leads to the internalization and degradation of both Fet3p and Ftr1p. Yeast strains defective in endocytosis (⌬end4) show a reduced iron-induced loss of
doi:10.1074/jbc.m414663200
pmid:15817488
fatcat:z75vbynn5ndd7dqluserjin3di