An efficient stereoselective synthesis of a sulfur-bridged analogue of bosseopentaenoic acid as a potential antioxidant agent

Yasser Mohamed, Eirik Johansson Solum
2017 ARKIVOC  
An efficient approach to the stereoselective synthesis of a novel sulfur-bridged analogue of bosseopentaenoic acid (BPA) by employing the Z-selective modified Boland semi-reduction procedure as the key step is described. The free radical scavenging potential of the thiophene analogue of bosseopentaenoic acid is studied. The results showed that the thiophene ring led to increased antioxidant activity. S Z Z E E Z E E Z Z Z COOR COOR 5a R= H 5b R= CH 3 6a: R=H 6b: R=CH 3 Rigidification of
more » ... le bonds by introduction of thiophene moiety to BPA structure
doi:10.24820/ark.5550190.p010.086 fatcat:vos3idpixvc4hocxtzu3t45jjq