The integrative model of human physiology connects individual physiological subsystems into a single unit. They are enormous (contain thousands of variables) and represent a formalized description of interconnected physiological regulations. The issue of formalization of physiological systems became part of a series of international projects (e.g. the worldwide program "PHYSIOME", or the European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiology

more »

... s facilitated by a new generation (i.e. equation-based) of simulation environments, especially by the Modelica language. These models can be used to explain the causal relations of the pathogenesis of many diseases. They can be applied in the evaluation of clinical trials and they can also be used in the core of sophisticated medical simulators. Figure 2. Interconnected physiological subsystems in the Guyton model (Guyton et al., 1972).