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The integrative model of human physiology connects individual physiological subsystems into a single unit. They are enormous (contain thousands of variables) and represent a formalized description of interconnected physiological regulations. The issue of formalization of physiological systems became part of a series of international projects (e.g. the worldwide program "PHYSIOME", or the European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiologydoi:10.3384/ecp17132589 dblp:conf/modelica/KofranekKMJS17 fatcat:d6ocusmaiveovomkwmviyg6uqi