GASTRORETENTIVE DRUG DELIVERY SYSTEM OF LAMOTRIGINE: IN VIVO EVALUATION

Geeta Yadav, Sushma Singh
unpublished
ABSTARCT Objective: The aim of this study was to develop intragastric bilayer floating tablets of an anti-convulsant drug Lamotrigine using simple and convenient methods in an attempt to provide extended release profile with the floating efficiency. Methods: Detailed Drug-excipient compatibility studies were performed at different temperature and humidity conditions using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The floating bilayer tablets
more » ... bilayer tablets were prepared using Direct compression (DC). HPMC K100M, Ethyl cellulose and sodium alginate were used for extending the drug release. The polymer contents were optimized using factorial design. In-vivo gastroretention studies were performed in fasted rabbit. Results: The floating tablets were found to be having acceptable hardness and friability. 99% dissolution of the final optimized batch was achieved up to 24 hrs. The tablets were found to be floating for 24 hrs in rabbit. Conclusion: It is concluded that Lamotrigine can be given for extended release profile. This study has solved the problem of alkaline instability of Lamotrigine and has a great industry prospect.
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