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ABSTARCT Objective: The aim of this study was to develop intragastric bilayer floating tablets of an anti-convulsant drug Lamotrigine using simple and convenient methods in an attempt to provide extended release profile with the floating efficiency. Methods: Detailed Drug-excipient compatibility studies were performed at different temperature and humidity conditions using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The floating bilayer tabletsfatcat:a6igoogllza4zchdox64zzvbxq