Date Seed Extract Diminished Apoptosis Event in Human Colorectal Carcinoma Cell Line

Mohsen Rezaei
2015 MOJ Toxicology  
Apoptosis, or programmed cell death, is an essential process to remove the damaged or abnormal cancerous cells. Therefore, the study of apoptosis-inducing agents helps identifying new drugs for cancer therapy. The aim of this study was to evaluate the apoptotic effect of methanolic extract of date seed in human colon cancer cell. HT29 cells were cultured and exposed to different concentrations of date seed extract (100, 200 and 400µg/ml). Neutral comet assay was used and the patterns were
more » ... fied into four groups based on the tail length and head size. Results showed that the extract has not been able to induce apoptosis in HT29 cells. Amazingly, the rate of apoptosis observed in the HT29 cells exposed to the extract, was lower than the negative control group that received no treatment. While the methanolic extract of date seed did not induce apoptosis in colon tumor cells its supporting effect on HT29 cells survival may fuels more investigation.
doi:10.15406/mojt.2015.02.00017 fatcat:zbzjiuqndba3dmsmh7jmtxsddi