SECONDARY FIBRINOLYSIS, PROTEIN C ACTIVATION, PLATELET DECREASE, BUT NOT CONTACT ACTIVATION CAN BE CORRELATED TO FREE THROMBIN ACTION IN EXPERIMENTAL DIC

G Marbet, P Satiropas, C Pantaleoni, F Duckert
1987 DIET   unpublished
We have studied the influence of activated coagulation on antithrombotic defence mechanisms in vivo. Conventional coagulation variables, platelets (Tcy), plasminogen (Pig), α2-antiplasmin (AP) , protein C (PC), factor VIII C, factor XII and Cl-inhibitor have been measured before and during reversible tissue thromboplastin-induced DIC in the dog. Free thrombin action as derived from fibrinogen (Fbg) decrease has been expressed as integral of active thrombin concentration over time (φ).
more » ... by heparin H, pentosan polysulfate PPS or dermatan sulfate DS was studied. DIC had no consistent effect on the behaviour of factor XII and Cl-inhibitor, but led to the consumption (Δ) of the following variables:The Spearman correlation coefficients between and φ in the Δ whole group were all statistically significant and ranged from rs=0.51 (ΔPlg) to rs =0.94 (ΔFbg). The response of major defense mechanisms in vivo quantitatively depends on active thrombin.
doi:10.1055/s-0038-1643576 fatcat:bvxqbyginjdnzimn2vdwaet334