On immunotherapies and cancer vaccination protocols: A mathematical modelling approach

Badal Joshi, Xueying Wang, Sayanti Banerjee, Haiyan Tian, Anastasios Matzavinos, Mark A.J. Chaplain
2009 Journal of Theoretical Biology  
In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and costimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive immunotherapy protocols can sometimes promote tumor growth instead of inhibiting it (a phenomenon called
more » ... ulation), as opposed to active vaccination protocols based on tumor-antigen pulsed dendritic cells. Significantly, our simulations suggest that elevated numbers of professional antigen presenting cells correlate well with prolonged time periods of cancer dormancy.
doi:10.1016/j.jtbi.2009.05.001 pmid:19446568 fatcat:niak7bxggvhllhyiu3y3sgebau