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In this paper we develop a new mathematical model of immunotherapy and cancer vaccination, focusing on the role of antigen presentation and costimulatory signaling pathways in cancer immunology. We investigate the effect of different cancer vaccination protocols on the well-documented phenomena of cancer dormancy and recurrence, and we provide a possible explanation of why adoptive immunotherapy protocols can sometimes promote tumor growth instead of inhibiting it (a phenomenon calleddoi:10.1016/j.jtbi.2009.05.001 pmid:19446568 fatcat:niak7bxggvhllhyiu3y3sgebau