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Modeling Transcriptional Control in Gene Networks—Methods, Recent Results, and Future Directions
2000
Bulletin of Mathematical Biology
Mathematical models are useful for providing a framework for integrating data and gaining insights into the static and dynamic behavior of complex biological systems such as networks of interacting genes. We review the dynamic behaviors expected from model gene networks incorporating common biochemical motifs, and we compare current methods for modeling genetic networks. A common modeling technique, based on simply modeling genes as ON-OFF switches, is readily implemented and allows rapid
doi:10.1006/bulm.1999.0155
pmid:10824430
fatcat:lqoe2gmkznahvgleafh24m2w6i