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Graphical Abstract Highlights d The 20S proteasome subunit PSMA7 is subjected to ubiquitin-proteasomal degradation d PSMA7 degradation is suppressed by c-Abl-mediated tyrosine phosphorylation at Y106 d Proteasome abundance is decreased by c-abl/arg knockout or Abl kinase inhibition d c-Abl plays dual roles in the regulation of proteasome homeostasis and activities SUMMARY The ubiquitin-proteasome system is a vital proteolytic pathway required for cell homeostasis. However, the turnoverdoi:10.1016/j.celrep.2014.12.044 pmid:25620702 fatcat:5mzg24fcm5fprixy3s4yfzf2ti