Ovarian neoplasms constitute a major bulk of surgical pathology specimens. Histopathology is the gold standard in diagnosis. Of the many options available for a rapid intra-operative diagnosis imprint cytology has many advantages. This study therefore aimed to study the imprint cytology of ovarian lesions and compare with the histopathology findings and analyze the statistical effectiveness of this study as a rapid intra-operative diagnostic tool. Methods: 200 lesions resected over a 2 year

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... od were included in the study. Lesions were bisected when fresh. Clean glass slides touched firmly over the representative areas. Immediate fixation was in 95% ethanol and staining was by Rapid Papanicolaou method. Of the 200 cases studied, 5 were lost to follow up, and hence were excluded from the study. Results: The 195 cases were classified broadly according to WHO system into 4 groups and the lesions were statistically analyzed. 122 surface epithelial tumors showed 97.5%sensitivity and 94.5%specificity in diagnosis with an overall accuracy of 96.4%. 8 sex cord stromal tumors had 98.5% diagnostic accuracy with a specificity of 99.5%. There was 100 % sensitivity and specificity in diagnosing the 25 germ cell tumors. The tumor like lesions showed a diagnostic accuracy of 97% with a specificity of 100%. Conclusions: Imprint cytology is an inexpensive and a fairly sensitive tool for rapid intra-operative diagnosis.