©2015 Ruolin Wang ALL RIGHTS RESERVED PROFILE ANALYSIS AND IN VITRO ABSORPTION STUDY OF CITRUS PEEL POLYMETHOXYFLAVONES ABSTRACT OF THE THESIS Profile Analysis and In Vitro Absorption Study of Citrus Peel Polymethoxyflavones

Ruolin Wang, Ruolin Wang, Chi-Tang Ho
unpublished
Polymethoxyflavones (PMFs) are a group of flavonoids found exclusively in citrus genus that have been identified with many potent biological activities, including anti-inflammation, anti-cancer, anti-atherosclerosis, and antioxidant. However, the bioavailability of PMFs is seldom studied. As far as we know, PMFs have poor aqueous solubility, and may potentially have high permeability due to their lipophilic structure. Biological studies rely on efficient separation method to obtain pure
more » ... obtain pure compounds. Silica gel column chromatography was utilized in this study to separate individual PMFs from aged orange peel extracts, and the yielded products had more than 95% purity. With this established method, purified PMF derivatives from chemical modification were also obtained. iii
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