Non-specific laryngeal granuloma is a rare inflammatory mass. Its etiology is still unclear. We herein report the retrospective review of 46 patients with non-specific laryngeal granuloma who visited our clinic from 1982 to 1999. Thirty-two out of 46 cases were contact granuloma, and 14 were intubation granuloma. Thirty-six cases were male and 10 were female. In male cases, 83% (30/36) were contact granuloma, while in female, 80% (8/10) were intubation granuloma. Endolaryngeal microsurgery

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... CO2 laser was performed for 43 patients as an initial treatment. In the surgical cases, there was recurrence in 65% and 25% of patients with contact granuloma and intubation granuloma, respectively. Beclomethasone dipropionate inhaler (BDI) was used in 7 cases (two with contact granulomas and five with recurrent granulomas). No recurrence was observed in the cases treated by BDI. Proton pump inhibitor (PPI) and Fluticasone propionate dry powder inhaler (FPI) were used for a contact granuloma patients. The granuloma decreased remarkably in size. Conservative therapies such as steroid inhalation and or PPI administration should be adopted as the initial treatment for non-specific granuloma. Untreated surgical excision should be avoided because of its high recurrence rate.