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Early induction of antibacterial activities distinguishes response of mice to infection with non-permissive from response to permissive Salmonella
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid in humans, shares very high homology with closely related serovar, S. Typhimurium. Yet, unlike S. Typhimurium, S. Typhi does not establish infection in mice. We show that intraperitoneal infection of mice with S. Typhi is associated with induction of antibacterial activities. Cell-free peritoneal fluids from S. Typhi but not S. Typhimurium-infected mice inhibited replication of Salmonella ex vivo. Administration ofdoi:10.1101/2020.12.07.414268 fatcat:bsaxqq64snahdlx62mu3dpl7lm