Could Abnormal Distribution of Interstitial Cells of Cajal be Involved in Gastrointestinal Disorders in Patients with Parkinson's Disease?

HOU Xiaojun
2018 Archives in Neurology & Neuroscience  
The colon showed two c-kit positive cells: one in the mucosal layer with a large cell body and a round shape that was identified This work is licensed under Creative Commons Attribution 4.0 License ANN.MS.ID.000525. Abstract Objective: To study the role of interstitial cells of Cajal (ICC) in the pathogenesis of gastro-intestinal motility disorders in Parkinson's disease (PD). Methods: The distribution of ICCs was studied by immunohistochemical analysis using anti c-kit antibodies in 4 cases of
more » ... odies in 4 cases of PD patients and 4 paired non-PD patients. Results: ICCs were located in the inner part of the circular muscle and around the myenteric plexus between the two muscle layers. The number of c-kit+ ICCs was remarkably reduced or even disappeared in patients with PD. Conclusion: The lack of ICCs may lead to the abnormal spontaneous electrical activity and conduction which gives rise to gastrointestinal motility disorders in PD.
doi:10.33552/ann.2018.01.000525 fatcat:efdtoa6fljdv5py4ts52gylvva