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Considering all the PDB annotated allosteric proteins (from ASD - AlloSteric Database) belonging to four different classes (kinases, nuclear receptors, peptidases and transcription factors), this work has attempted to decipher certain consistent patterns present in the residues constituting the allosteric communication sub-system (ACSS). The thermal fluctuations of hydrophobic residues in ACSSs were found to be significantly higher than those present in the non-ACSS part of the same proteins,arXiv:1802.10207v1 fatcat:c3vz2qmdt5a3pbzk2x4tjlb64m