Fluoroquinolone Resistance inStreptococcus pyogenes

Sandra S. Richter, Daniel J. Diekema, Kris P. Heilmann, Laurel S. Almer, Virginia D. Shortridge, Rod Zeitler, Robert K. Flamm, Gary V. Doern
2003 Clinical Infectious Diseases  
Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 mg/mL) was found. DNA amplification and sequencing revealed a serine 81 r tyrosine substitution in gyrA and 2 substitutions in parC: serine 79 rphenylalanine and alanine 121 rvaline. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
doi:10.1086/345904 pmid:12539083 fatcat:yxavil3vqncr5ev6xj4tzt42oq