The role of skin and subcutaneous tissues in Dupuytren's contracture: an electron microscopic observation

Wu Chen, Hao Zhou, Zhi-jun Pan, Jian-song Chen, Li Wang
2009 Orthopaedic Surgery  
Objective: To determine the relationship between the overlying tissues and recurrence of Dupuytren's contracture. Methods: Forty-three patients (68 hands) who accepted surgical treatment were divided into two groups according to treatment methods: partial fasciectomy or dermofasciectomy and full-thickness skin graft. Diseased palmar fascia, subcutaneous tissues and skin obtained during surgery were then assessed by electron microscopy. Results: All patients were followed up. None of the hands
more » ... ich accepted dermofasciectomy and full-thickness skin grafting recurred, while 46.4% of the hands which accepted partial fasciectomy recurred. Under electron microscopic observation, myofibroblasts were found in the skin and subcutaneous tissues. Conclusion: The overlying tissues play an important role in Dupuytren's contracture, which may be a reason for recurrence of this condition after surgical treatment.
doi:10.1111/j.1757-7861.2009.00028.x pmid:22009846 fatcat:lx74vfztl5enldnpolkxldcoua