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Co-opting the cellular machinery for protein production is a compulsory requirement for viruses. The Cricket Paralysis virus employs an Internal Ribosomal Entry Site (IRES) to express its structural genes in the late stage of infection. Ribosome hijacking is achieved by a sophisticated use of molecular mimicry to tRNA and mRNA, employed to manipulate intrinsically dynamic components of the ribosome. Binding and translocation through the ribosome is required for this IRES to initiatedoi:10.1101/230615 fatcat:66arofhp4vg4rpo3mawecorhvy