EFFECT OF CHRONIC COLD RESTRAINT AND IMMOBILIZATION STRESS ON ESTROUS CYCLE IN RATS

C Saraswathi, Sathyanarayan Sreemantula, Wagh Prakash, C Saraswathi
unpublished
Chronic stress is known to produce a state of dyshomeostasis (allostasis) that involves significant behavioral, endocrinological and neurobiological changes. The underlying mechanisms and complications of which are not clearly understood. The present study aims at investigating the effect of chronic cold restraint (a moderate physical/metabolic stressor) and immobilization (physical and psychological stress) on estrous cycle in rats. It was found that stress produces a significant increase in
more » ... icant increase in proestrous phase indicating the non maturation of follicles, supported by histopathological studies. The serum levels of glucose, cholesterol and triglycerides were decreased. Corticosterone levels were increased. Ovary and uterus weight was decreased due to the non availability of hormones. Adrenal gland weight was increased indicating hypertrophy. All the above observations shows stress produces a significant change in the estrous cycle.
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