Liver Function Tests in Patients of Acute Leukemia before and after Induction Chemotherapy

Tahmidul Islam, A. K. M. Shahidur Rahman, Md. Kamrul Hasan, Ferdous Jahan, Manik Chandra Mondal, Manik Chandra Mondal, Sheuly Ferdoushi, Sabrina Alam, Mohammad Kamrul Ahsan, Jannatut Tasnim, Sharaban Tohura
2020 Journal of Biosciences and Medicines  
Patients of acute leukemia require careful assessment of liver function prior to start chemotherapy to determine which drugs may be appropriate or to be modified. Post chemotherapy abnormalities of liver function tests may be due to drugs or due to disease process itself. Objective: To evaluate the status of liver function in acute leukemia patients before and after induction chemotherapy. Methodology: This was a prospective cross-sectional study conducted in the on fifty (50) newly diagnosed
more » ... ) newly diagnosed patients of acute leukemia who fulfilled the selection criteria. Blood samples for serum total bilirubin, alanine transaminase (ALT) and aspartate transaminase (AST) were collected before chemotherapy (Day 1) and after induction chemotherapy on 14 th day and 30 th day. Serum ALT and AST were measured by kinetic method and serum total bilirubin was measured by DMSO method. Data were analyzed and compared by statistical tests. Result: In this study, the mean level of serum total bilirubin before chemotherapy at day 1 was 0.89 ± 0.64 mg/dl. It was significantly (p < 0.001) raised to 1.55 ± 1.05 mg/dl at day 14 of chemotherapy, and again significantly (p < 0.002) reduced to 0.72 ± 0.35 mg/dl at day 30 of chemotherapy as compared to day 1. Similarly the mean serum ALT at day 1 was 47.46 ± 15.
doi:10.4236/jbm.2020.82009 fatcat:27htugqncvho5f2npdtai5i6em