The basic parameters of cellular immunity and leukocyte composition of peripheral blood of children suffering HGVI caused by herpes viruses of I-VI types, age groups 3-5, 6-11, 12-14 years, corresponding to different degrees of maturity of immune system, were studed. Regardless of age, a significant change in the quantity and composition of lymphoid subpopulations of leukocytes observedin patients with persistent groups of 3 or more types of herpes viruses in leukocytes. Typical for these

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... ts allsurveyed age groups are lack of cell subpopulations of T-cytotoxic (CD8+) and T-active (HLA-DR +) lymphocytes and decreased functional capacity of T-lymphocytes (except for patients 12-14 years old) as a spontaneous andstimulated PHA blastogenesis. The most numerous irregularities characterized by cellular immunity HGVI with younger children (3-5 years). Regardless of the viral load in all patients 3-5 years, and a group with high viral load is observed 6-11 multiple increase of activated T-lymphocytes (CD25 +) against a significant reduction ofT lymphocyte apoptosis markers (CD3 + CD95 +). With increasing age of the children with the HGVI, the amount of the changed parameters of cellular immunity in charge of anti-virus protection is reduced. Thus more rapid and complete normalization observed in patients infected with1-2 herpes viruses.