FEATURES OF CELLULAR IMMUNITY IN CHILDREN WITH CHRONIC HERPES VIRUS INFECTION DEPENDING ON THE AGE AND DEGREE OF EXPOSURE TO THE DIFFERENT TYPES VIRUSES
Anali Mečnikìvsʹkogo Institutu
The basic parameters of cellular immunity and leukocyte composition of peripheral blood of children suffering HGVI caused by herpes viruses of I-VI types, age groups 3-5, 6-11, 12-14 years, corresponding to different degrees of maturity of immune system, were studed. Regardless of age, a significant change in the quantity and composition of lymphoid subpopulations of leukocytes observedin patients with persistent groups of 3 or more types of herpes viruses in leukocytes. Typical for these
... ts allsurveyed age groups are lack of cell subpopulations of T-cytotoxic (CD8+) and T-active (HLA-DR +) lymphocytes and decreased functional capacity of T-lymphocytes (except for patients 12-14 years old) as a spontaneous andstimulated PHA blastogenesis. The most numerous irregularities characterized by cellular immunity HGVI with younger children (3-5 years). Regardless of the viral load in all patients 3-5 years, and a group with high viral load is observed 6-11 multiple increase of activated T-lymphocytes (CD25 +) against a significant reduction ofT lymphocyte apoptosis markers (CD3 + CD95 +). With increasing age of the children with the HGVI, the amount of the changed parameters of cellular immunity in charge of anti-virus protection is reduced. Thus more rapid and complete normalization observed in patients infected with1-2 herpes viruses.