SUCCINATE DEHYDROGENASE AND EOSINOPHILS AS BIOMARKERS OF HYMENOLEPIASIS

J Parvathi, K Aruna
2012 Online) An Online International Journal Available at   unpublished
Disease producing organisms require a highly specialized environment for their growth and propagation, usually found only in the tissues of man or other animals. Although the morbidity and mortality due to such infections is not alarming, they adversely affect the general health and productivity of adults, mental and physical growth of children, especially those suffering from malnutrition. Hymenolepis nana (dwarf tapeworm) is one such common cosmopolitan intestinal parasite of man and mouse,
more » ... of man and mouse, which can persist in a single host for many years, leading to even crowding effect, traumatizing the host further. As a cestode helminth, the hallmark of its infection is eosinophilia, a common biomarker of helminthiasis. But succinate dehydrogenase, a key enzyme of the energy generating kreb's cycle, at the succinate-fumarate junction is also a potential biomarker, since; kreb's cycle is bi-directional in helminthes and uni-directional in the host. The excess of succinate is released by the parasite into the host, later to be absorbed by the host. In the present investigation, a quantitative increase in eosinophils and a qualitative increase in succinate dehydrogenase activity (demonstrated histochemically), have been observed. Thus, any deviations at this junction of this energy cycle, mediated by succinate dehydrogenase can be successfully interpreted for combating the parasitic attack. Hence eosinophils and succinate dehydrogenase levels in a traumatized host can be used as effective biomarkers, and utilized for the development of specific chemotherapy and vaccines.
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