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Giant cell tumors (GCT) are benign tumors that may have aggressive behavior, it is usually found peri-articular, (Distal femur, proximal tibia, distal radius) with unclear pathogenesis. Aim of the Work: To detect best method of treatment of aggressive giant cell tumor whether intralesional curettage or resection and replacement with endoprothesis. Patients and Methods: This review was a randomized controlled trial that studied the lines of surgical treatment of aggressive giant cell tumor. Thisdoi:10.21608/asmj.2020.148945 fatcat:pcps6xet2ng2vck6jakdqedsry