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Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes
American Journal of Physiology. Heart and Circulatory Physiology
The central nervous system (CNS) pericytes play an important role in brain microcirculation. Na ϩ /H ϩ exchanger isoform 1 (NHE1) has been suggested to regulate the proliferation of nonvascular cells through the regulation of intracellular pH, Na ϩ , and cell volume; however, the relationship between NHE1 and intracellular Ca 2ϩ , an essential signal of cell growth, is still not known. The aim of the present study was to elucidate the role of NHE1 in Ca 2ϩ signaling and the proliferation ofdoi:10.1152/ajpheart.01203.2007 pmid:18263712 fatcat:rtjuagxdrner5oc7zu3xh5r5di