Melanin-Concentrating Hormone Receptor Is a Target of Leptin Action in the Mouse Brain

Efi G. Kokkotou, Nicholas A. Tritos, Jason W. Mastaitis, Lawrence Slieker, Eleftheria Maratos-Flier
2001 Endocrinology  
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that is important in the regulation of energy homeostasis. MCH signals via a seven-transmembrane G protein-coupled receptor, which is coupled to G␣ i . This receptor was initially cloned in rat and human and designated SLC-1 because of its homology to the somatostatin receptor. In rat brain, it is expressed in a pattern that mirrors the previously described pattern of projections of MCH-immunoreactive fibers. In the present
more » ... In the present study we cloned the mouse MCH receptor (MCH-R) ortholog by a rapid amplification of 5Ј-and 3Ј-cDNA ends approach and have found it to be 98% homologous with the rat sequence. We have characterized MCH-R messenger RNA distribution in the mouse
doi:10.1210/endo.142.2.7981 pmid:11159839 fatcat:4csb5vnknjh4zki7xx3nobu63u