Maternal Hypoxia during Pregnancy Delays the Development of Motor Reflexes in Newborn Mice

Hava Golan, Irena Kashtutsky, Mordechai Hallak, Yoram Sorokin, Mahmoud Huleihel
2004 Developmental Neuroscience  
Prenatal hypoxic-ischemic brain injury is believed to cause permanent neurological defi cits in newborns. We investigated the possibility that maternal hypoxia during pregnancy leads to offspring brain damage and its prevention by i.p. administration of MgSO 4 . Pregnant mice at gestation day 17 were exposed to hypoxia or air following pretreatment with saline or Mg. Newborn mice to mothers exposed to hypoxia demonstrated faster development of morphogenic parameters such as eyelid opening, hair
more » ... yelid opening, hair growth and teeth eruption. In addition, hypoxia delayed the development of motor refl exes. Pretreatment with Mg compensates for hypoxiainduced impairment and in some cases accelerates the development of these functions. In conclusion, maternal hypoxia signifi cantly modifi es the developmental process of newborn mice. In our study, pretreatment with Mg showed signifi cant prophylactic action against motor impairments.
doi:10.1159/000080708 pmid:15509895 fatcat:hkxqd34onveizj7wr77othz7k4