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Prenatal hypoxic-ischemic brain injury is believed to cause permanent neurological defi cits in newborns. We investigated the possibility that maternal hypoxia during pregnancy leads to offspring brain damage and its prevention by i.p. administration of MgSO 4 . Pregnant mice at gestation day 17 were exposed to hypoxia or air following pretreatment with saline or Mg. Newborn mice to mothers exposed to hypoxia demonstrated faster development of morphogenic parameters such as eyelid opening, hairdoi:10.1159/000080708 pmid:15509895 fatcat:hkxqd34onveizj7wr77othz7k4