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Munc-18-1 Inhibits Phospholipase D Activity by Direct Interaction in an Epidermal Growth Factor-reversible Manner
Journal of Biological Chemistry
Mammalian phospholipase D (PLD) has been reported to be a key enzyme for epidermal growth factor (EGF)induced cellular signaling, however, the regulatory mechanism of PLD is still unclear. In this report, we found that Munc-18-1 is a potent negative regulator of PLD in the basal state and that its inhibition is abolished by EGF stimulation. We investigated PLD-binding proteins obtained from rat brain extract, and identified a 67-kDa protein as Munc-18-1 by peptide-mass fingerprinting. Thedoi:10.1074/jbc.m310976200 pmid:14744865 fatcat:v5ayegcngrgttntrbbedozxtli