The Specific Treatment of Typhoid Fever

William Royal Stokes, H. W. Maldeis
1919 Boston Medical and Surgical Journal  
The first attempt to establish a specific therapy for typhoid fever was made by E. FraenkeP in 1893. He treated 57 cases with intramuscular injections of killed thymus bouillon cultures of the typhoid bacillus. He began with a dose of 0.5 of a c.c., followed by 1 c.c. in 24 hours. These injections often caused a marked drop in the temperature but in two days the temperature often rose again, and an injection of 2 c.c. was often necessary to cause a second and
doi:10.1056/nejm191911271812201 fatcat:dvl7qtqfhbc25ckc2gkt7wzfeq