The aim of this study was to investigate the effect of small intestinal submucosa (SIS) on the healing of intestinal anastomosis in goats. Twelve local breed bucks were used. Animals were divided into two equal groups, in the first group the anastomotic site after resection of 4 cm from the jejunum was sutured by horizontal mattress pattern, considered as a control group. In the second group, after anastomose was covered by small intestinal submucosa,prepared previously and fixed with the

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... motic site by multiple stitches of a simple interrupted suture. Experimental animals were observed clinically, after 15 and 30 days postoperation, the sample of anastomosis site were examined grossly and histopathologically. Grossly in control group moderate to severe adhesion of anastomotic site with the surrounding tissue was found as compared with the moderate adhesion in the treated group. The bursting pressure, in control group, was (150±2.9) and (178.3±4.5) mmHg, while in the treated group was (185±2.9) and (208.3±4.5) mmHg at a period of 15 and 30 days post operation respectively. The degree of stenosis in control group was (59±1.5) and (49±2.2), while in the treated group was (76±5.6) and (36.3±0.6) at a period of 15 and 30 days post operation respectively. The histopathological findings revealed that the healing process was more prominent in the treated group than in the control group. In conclusion of this study investigated that submucosa of small intestine enhances healing of intestinal anastomosis.