Genetic and Environmental Effects on Fasting and Postchallenge Plasma Glucose and Serum Insulin Values in Finnish Twins

Shuichi Katoh, Mikko Lehtovirta, Jaakko Kaprio, Valma Harjutsalo, Markku Koskenvuo, Johan Eriksson, Naoko Tajima, Jaakko Tuomilehto
2005 Journal of Clinical Endocrinology and Metabolism  
The aim of this study was to evaluate genetic and environmental effects on plasma glucose, insulin secretion, and resistance in Finnish twins. Altogether 151 randomly selected twin pairs were examined by the oral glucose tolerance test; 66 twin pairs were monozygotic and 85 like-sexed dizygotic. We estimated the intraclass correlation coefficients and variance components of genetic and environmental effects on waist circumference, plasma glucose, and serum insulin. For fasting insulin, the
more » ... rtion of total variation accounted for by additive genetic effects (A) and nonshared environmental effects (E) were 43 and 57%, respectively. As to postchallenge insulin and waist circumference, A effects were stronger in * S.K. and M.L. share the first authorship Abbreviations: A, Additive genetic component; BMI, body mass index; C, environmental component; CI, confidence interval; df, degrees of freedom; DZ, dizygotic; Gluc, plasma glucose; E, environmental component; h 2 , heritability; HOMA-BETA, homeostasis model of ␤-cell function; HOMA-R, homeostasis model of insulin resistance index; Ins, serum insulin; MZ, monozygotic; OGTT, oral glucose tolerance test; WHR, waist to hip ratio. JCEM is published monthly by The Endocrine Society (http://www. endo-society.org), the foremost professional society serving the endocrine community.
doi:10.1210/jc.2004-2471 pmid:15728197 fatcat:543l6u33yjaprgengmpsgy4mha